当前位置：首页>郑州>博士毕业四川大学华西医院,曾就职郑州大学,重庆医科大学研究员发表最新研究成果

博士毕业四川大学华西医院,曾就职郑州大学,重庆医科大学研究员发表最新研究成果

  • 2026-03-31 08:46:27
博士毕业四川大学华西医院,曾就职郑州大学,重庆医科大学研究员发表最新研究成果
2026年1月27日，重庆医科大学附属第二医院路芳慧联合附属第一医院唐兆华以及基础医院邓娅琦在 The Journal of Clinical Investigation 发表题为 “Oligodendrocyte transcription factor 2 orchestrates glioblastoma immune evasion by suppressing CXCL10 and CD8+T cell activation”的研究论文，系统揭示了OLIG2驱动GBM免疫逃逸并介导免疫治疗耐药的分子机制。

研究发现OLIG2通过招募组蛋白去乙酰化酶HDAC7，形成转录抑制复合物，直接抑制关键趋化因子CXCL10的表达，从而限制CD8⁺ T细胞募集与激活，塑造免疫抑制性肿瘤微环境。更重要的是，遗传或药理学抑制OLIG2可显著增强PD-L1抑制剂的抗肿瘤疗效，为GBM的联合免疫治疗提供了新的突破口。

路芳慧研究员聚焦神经肿瘤微环境可塑性与肿瘤治疗抵抗机制，取得了一系列原创成果，相关研究以一作/通讯（含共同）发表在 Cancer Cell 等权威杂志上。作为项目负责人主持国家自然科学基金3项，获重庆市“巴渝青年学者。

原文链接：

https://www.jci.org/articles/view/195556

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  1. CONNECT:[ UseTime:0.001180s ] mysql:host=127.0.0.1;port=3306;dbname=i460;charset=utf8mb4
  2. SHOW FULL COLUMNS FROM `fenlei` [ RunTime:0.002194s ]
  3. SELECT * FROM `fenlei` WHERE `fid` = 0 [ RunTime:0.001140s ]
  4. SELECT * FROM `fenlei` WHERE `fid` = 63 [ RunTime:0.000730s ]
  5. SHOW FULL COLUMNS FROM `set` [ RunTime:0.001713s ]
  6. SELECT * FROM `set` [ RunTime:0.000625s ]
  7. SHOW FULL COLUMNS FROM `article` [ RunTime:0.001937s ]
  8. SELECT * FROM `article` WHERE `id` = 491213 LIMIT 1 [ RunTime:0.001073s ]
  9. UPDATE `article` SET `lasttime` = 1775353330 WHERE `id` = 491213 [ RunTime:0.006144s ]
  10. SELECT * FROM `fenlei` WHERE `id` = 64 LIMIT 1 [ RunTime:0.000685s ]
  11. SELECT * FROM `article` WHERE `id` < 491213 ORDER BY `id` DESC LIMIT 1 [ RunTime:0.001343s ]
  12. SELECT * FROM `article` WHERE `id` > 491213 ORDER BY `id` ASC LIMIT 1 [ RunTime:0.001332s ]
  13. SELECT * FROM `article` WHERE `id` < 491213 ORDER BY `id` DESC LIMIT 10 [ RunTime:0.002346s ]
  14. SELECT * FROM `article` WHERE `id` < 491213 ORDER BY `id` DESC LIMIT 10,10 [ RunTime:0.003886s ]
  15. SELECT * FROM `article` WHERE `id` < 491213 ORDER BY `id` DESC LIMIT 20,10 [ RunTime:0.009644s ]
0.252120s